Mannich Reaction

This multi-component condensation of a nonenolizable aldehyde, a primary or secondary amine and an enolizable carbonyl compound affords aminomethylated products. The iminium derivative of the aldehyde is the acceptor in the reaction.

The involvement of the Mannich Reaction has been proposed in many biosynthetic pathways, especially for alkaloids.

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Mechanism of the Mannich Reaction

Recent Literature

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